SystemAge vs. TruDiagnostic: Comprehensive Comparison of Top Biological Age Tests

June 6, 2025

Now that the science of longevity is shifting from lab benches to living rooms, the frontier of biological age testing is emerging. Early adopters in the longevity movement and health optimizers are no longer questioning if they should measure how fast they're aging. Instead, they want to know how.

Two of the most science-backed players in this space are SystemAge, developed by Generation Lab, and TruDiagnostic, the team behind the TruAge and TruHealth testing kits. Both claim to deliver groundbreaking insights into your aging trajectory, but they differ sharply in science and real-world application.

So, which is the best biological age test? Let’s find out in this SystemAge vs TruDiagnostic review.

Introduction to Biological Age Testing

Biological age testing is an innovative approach that measures how old your body truly is at the cellular and molecular levels, rather than simply counting the years since your birth. Unlike chronological age, which is fixed, biological age reflects the cumulative effects of genetics, lifestyle, environment, and health status on your body’s systems.

DNA methylation analysis and epigenetic age tests are used to get a picture of your overall aging process. The insights can help identify areas of accelerated aging and guide targeted interventions for healthier longevity.

Comparative Analysis: SystemAge vs. TruDiagnostic

Below, we offer a TruDiagnostic and SystemAge review in several aspects, from the science behind them to their extent of personalization.

The Science

SystemAge spawned from 20+ years of cutting-edge aging research led by UC Berkeley bioengineering professor Dr. Irina Conboy. As a pioneer in plasma-based rejuvenation, Dr. Conboy believes that aging is biological, not chronological, and can be slowed or even reversed through targeted interventions.

SystemAge boasts 99% accuracy in measuring biological age through DNA methylation, a process powered by Illumina technology, which analyzes the chemical modifications on DNA that change with age. The system is backed by over 14,000 citations and multiple peer-reviewed clinical validations.

Its biggest differentiator is that it tracks aging and the pace of aging across 19 distinct organ systems individually - from the brain and cardiac system to inflammation, metabolism, and beyond.

On the other hand, TruDiagnostic has built a strong reputation through collaborations with Harvard, Yale, and Duke. The company has developed over 1,670 epigenetic biomarkers for diagnostics. Its core algorithms include:

OMICmAge for overall biological age
SYMPHONYAge for 11 organ systems
DunedinPACE for the rate of aging
Additional insights like telomere length, immune health, cancer risk, etc

While both brands offer longevity diagnostics, SystemAge outpaces TruDiagnostic in granularity since it offers 19 organ-specific aging clocks compared to TruDiagnostic's 11.

Recent research has also raised important questions about the scientific foundation behind some of TruDiagnostic's core methods. A 2023 peer-reviewed study on the cover of Aging found that Elastic Net-based methylation clocks, which TruDiagnostic relies on, suffer from low predictive accuracy among individuals of the same age.

Source

The study also showed that the selection of methylation sites within these clocks shifts unpredictably when non-clock cytosines are removed from training data, undermining their reliability as consistent biological health markers.

In short, these clocks optimize for machine learning outcomes, not biological validity. These findings highlight a major difference between conventional clocks and SystemAge's "noise barometer" approach, which uniquely measures aging and emphasizes stability and biological relevance over mathematical prediction alone.

Real-World Usage

SystemAge is used by 150+ clinics, which use the test as the basis of longevity treatments and measurement efficacy for therapies and interventions. Clinicians use SystemAge to detect early risk signals before symptoms arise, personalize treatments (e.g., NAD+, stem cells, plasma exchange), and track the efficacy of these therapies.

In one case, patients undergoing plasma therapy showed a biological age reduction of over 10 years in the immune system alone. Building on its foundation as the gold standard of measurement for science and longevity experts, SystemAge is now expanding into new markets - consumers, gyms, corporate wellness programs, etc.

TruDiagnostic is a consumer-first brand with a wide product range. Its TruAge test focuses on biological aging metrics, while TruHealth analyzes nutritional, metabolic, and toxin-related biomarkers.

It offers data, especially for those seeking lifestyle and diet insights alongside aging metrics. The at-home convenience and broad biomarker coverage make it accessible, though not always clinically actionable.

Personalization and Actionability

SystemAge doesn't stop at telling you how fast you are aging, t helps you understand why you're aging the way you are and what to do about it.

Each organ-specific result comes with tailored recommendations, allowing you (and your physician) to personalize interventions and retest over time to measure progress. As a result, longevity transforms into a data-driven journey to stop the age clock.

Meanwhile, TruDiagnostic offers general recommendations and reports like "smoking impact score," "cancer risk," and "type 2 diabetes risk," alongside nutrient data. It's useful for broader wellness insights but lacks the same clinical-grade actionability when it comes to reversing biological age per organ system.

Design Philosophy

When it comes to SystemAge vs TruDiagnostic design philosophy, you will see a major difference in their positioning.

SystemAge positions itself as your biological "operating system report." It's built for high performers, clinic directors, and serious biohackers who want hard numbers and trackable outcomes.

It's sort of like the Oura Ring of biological age testing: specific, science-first, and mission-driven.

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TruDiagnostic, by contrast, caters more to the wellness generalist. These may be people interested in nutrition and general lifestyle optimization. Its wide net of biomarkers gives users a snapshot of health trends, but the depth of longevity-specific insights can vary. So, if you're looking for a revolutionary shift in aging control, SystemAge does the job better.

User Outcomes

The core emotional driver behind SystemAge is power and control. When you see your cardiac system aging twice as fast as your skin or brain, you no longer feel trapped in vague anti-aging marketing. You know what to fix, and you can track whether your plan is working.

The mechanism has triggered users to say, "I need to know my 19 numbers" moment for users. Clinics report better retention and revenue from retesting cycles, and early users consistently report lower dropout rates and improved lifestyle adherence.

In contrast, TruDiagnostic provides its users with a sense of discovery. It helps them understand how their lifestyle affects various health markers. But its messaging leans more into prevention and awareness than deep longevity reversal.

SystemAge vs TruDiagnostic: Pros and Cons

Let's take a closer look at the pros and cons of both longevity testing solutions.

SystemAge Pros and Cons

Pros

Measures 19 organ systems for detailed longevity insight
Clinically proven to reverse biological age (e.g., stem cells, plasma exchange)
Used in over 150 longevity clinics
99% accuracy with peer-reviewed validation
Provides personalized, organ-specific interventions
High retention and measurable outcomes over time

Cons

Newer to the direct-to-consumer market
Focused on aging metrics than on lifestyle markers like toxins or vitamins

TruDiagnostic Pros and Cons

Pros

Broad biomarker testing
Offers tests tailored for lifestyle, nutrition, and aging
Strong at-home test experience with wide accessibility

Cons

Tracks 11 organ systems
Less clinically actionable for reversing aging per organ
General recommendations, less specific to interventions

Conclusions

If you're a longevity diagnostics clinic, a biohacker, or a high-performance individual serious about reversing the clock organ by organ, SystemAge is the best biological age test for your needs. It can become the next-generation dashboard for your body's operating system.

However, if you're new to the space or are interested in exploring a wider wellness picture, including nutritional gaps or exposure to toxins, TruDiagnostic offers a solid entry point into epigenetic health.

But if you want to measure and reverse aging with precision and confidence, then it's time to ask: What are your 19 numbers?

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